Differential isoform expression of small conductance Ca-activated K channels, SK1, SK2 and SK3 channels in mouse atrial and ventricular myocytes
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چکیده
Address for correspondence and proofs: Nipavan Chiamvimonvat Division of Cardiovascular Medicine, Department of Medicine University of California, Davis Genome and Biomedical Sciences Facility 451 East Health Sciences Drive, Room 6315 Davis, CA 95616 voice: (530) 754-7158 fax: (530) 754-7167 email: [email protected] Articles in PresS. Am J Physiol Heart Circ Physiol (July 29, 2005). doi:10.1152/ajph art.00534.2005
منابع مشابه
Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes.
Small-conductance Ca2+-activated K+ channels (SK channels, KCa channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca2+ with membrane potential. We recently reported for the first time the functional existence of SK2 (KCa2.2) channels in human and mouse cardiac myocytes. Here, we report cloning of SK1 (KCa2.1) and SK3 (KCa2.3) channels from mo...
متن کاملCardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.
RATIONALE Ca(2+)-activated K(+) channels are present in a wide variety of cells. We have previously reported the presence of small conductance Ca(2+)-activated K(+) (SK or K(Ca)) channels in human and mouse cardiac myocytes that contribute functionally toward the shape and duration of cardiac action potentials. Three isoforms of SK channel subunits (SK1, SK2, and SK3) are found to be expressed....
متن کاملMolecular Medicine Cardiac Small Conductance Ca -Activated K Channel Subunits Form Heteromultimers via the Coiled-Coil Domains in the C Termini of the Channels
Rationale: Ca 2؉-activated K ؉ channels are present in a wide variety of cells. We have previously reported the presence of small conductance Ca 2؉-activated K ؉ (SK or K Ca) channels in human and mouse cardiac myocytes that contribute functionally toward the shape and duration of cardiac action potentials. Three isoforms of SK channel subunits (SK1, SK2, and SK3) are found to be expressed. Mor...
متن کاملSmall-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.
AIMS Small-conductance calcium-activated potassium (SK) channels are expressed in the heart of various species, including humans. The aim of the present study was to address whether SK channels play a functional role in human atria. METHODS AND RESULTS Quantitative real-time PCR analyses showed higher transcript levels of SK2 and SK3 than that of the SK1 subtype in human atrial tissue. SK2 an...
متن کاملMolecular properties of small-conductance Ca-activated K channels expressed in murine colonic smooth muscle
Ro, Seungil, William J. Hatton, Sang Don Koh, and Burton Horowitz. Molecular properties of small-conductance Ca21-activated K channels expressed in murine colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 281: G964–G973, 2001.—Small-conductance Ca21-activated K (SK) channels are important participants in inhibitory neurotransmission in gastrointestinal smooth muscles. Three isoform...
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تاریخ انتشار 2005